Thanks for highlighting the study! It is fascinating to dig more deeply into the details. The authors write: “Our results in zebrafish fn1b knockout model showed that reduced Fibronectin 1 increases the gliovascular (GV) endfeet retraction and reduces the gliosis. We previously showed that the relaxed GV contact is a beneficial response to amyloid toxicity as it helps enhance the clearance of toxic aggregates through the bloodstream.”
It is really cool that the observe these effects, especially in the light of aetiology of AD.
Thanks for highlighting the study! It is fascinating to dig more deeply into the details. The authors write: “Our results in zebrafish fn1b knockout model showed that reduced Fibronectin 1 increases the gliovascular (GV) endfeet retraction and reduces the gliosis. We previously showed that the relaxed GV contact is a beneficial response to amyloid toxicity as it helps enhance the clearance of toxic aggregates through the bloodstream.”
It is really cool that the observe these effects, especially in the light of aetiology of AD.