Great question! Interestingly, the cholesterol levels of these patients weren't abnormally low as one might expect for their severe HMG CoA reductase deficiency (But note the enzyme still has residual function). And mevalonate supplementation didn't affect the blood cholesterol levels of the patient either.
Cool, but wouldn't supplementing mevalonate be expected to cancel the cholesterol-lowering effects of statins?
Great question! Interestingly, the cholesterol levels of these patients weren't abnormally low as one might expect for their severe HMG CoA reductase deficiency (But note the enzyme still has residual function). And mevalonate supplementation didn't affect the blood cholesterol levels of the patient either.