Really clean write-up, and pinning the signal to the TG:HDL ratio rather than a single lipid fraction is what makes it land.
What I keep coming back to is how much the loss-of-function direction does for you here: a protective knockout that lines up across the human exome data and the Fnip1/Flcn mouse models is a very different animal from the usual GWAS hit, where you are guessing at both direction and mechanism.
Really clean write-up, and pinning the signal to the TG:HDL ratio rather than a single lipid fraction is what makes it land.
What I keep coming back to is how much the loss-of-function direction does for you here: a protective knockout that lines up across the human exome data and the Fnip1/Flcn mouse models is a very different animal from the usual GWAS hit, where you are guessing at both direction and mechanism.
Very well explained.......
Thank you!