Great point. MAPT was one of the genes of focus in the early gnomAD paper (https://www.nature.com/articles/s41586-020-2267-z) but the findings were inconclusive. At least in humans, there appears to be some mutational constraint. I am not aware of any knockouts reported so far for MAPT.
Are there tau knockouts in human population? Or tau aggregation resistant individuals? If so, do we have any close phenotyping of such individuals?
Great point. MAPT was one of the genes of focus in the early gnomAD paper (https://www.nature.com/articles/s41586-020-2267-z) but the findings were inconclusive. At least in humans, there appears to be some mutational constraint. I am not aware of any knockouts reported so far for MAPT.
So the reason why MAPT-KO mice exhibit normal phenotype is still uncovered?