GWAS Stories

A GWAS locus, all the way down

Twenty years after the association, the CD40 locus gives up its causal variant and the cell state it acts in.

Aug 16 • Veera M. Rajagopal

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FNIP1 loss and protection from metabolic diseases

A massive sequencing study identifies a key pathway in energy balance, and a drug target that was on no one's radar.

Aug 7 • Veera M. Rajagopal

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July 2026

May 2026

Drug development funnel: what I learnt building one from scratch

Thoughts on the cost of failures, the Phase II graveyard, and buying the race rather than the winner

May 10 • Veera M. Rajagopal

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November 2024

ASHG 2024 HIGHLIGHTS

Previewing Notable Talks and Posters

Nov 5, 2024 • Veera M. Rajagopal

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October 2024

Genomes vs Exomes

Whole genome sequencing vs whole exome sequencing: which one is cost-effective for gene discovery?

Oct 6, 2024 • Veera M. Rajagopal

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September 2024

Discovery of a major genetic risk factor for stroke in South Asians

Exome sequencing of 75k Pakistanis identifies a NOTCH3 genetic variant, accounting for 1-2% of strokes in South Asians

Sep 22, 2024 • Veera M. Rajagopal

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De novo enhancer creation by a noncoding mutation

Genetic investigation of a cardiac arrhythmia reveals a new noncoding Mendelian disease mechanism

Sep 15, 2024 • Veera M. Rajagopal

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August 2024

Discovery of TMEFF1, a viral restriction factor in the human brain

Exome sequencing of individuals with herpes simplex viral encephalitis identifies a new genetic mechanism through which neurons resist viral infections

Aug 18, 2024 • Veera M. Rajagopal

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4

The Big tau: A new hope for Alzheimer's?

An overlooked tau isoform may hold the key to an effective Alzheimer's drug

Aug 4, 2024 • Veera M. Rajagopal

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July 2024

How a jumping gene shaped the human skin color evolution

Two separate transposition events within ASIP, encoding agouti protein, have influenced the skin color changes during human evolution

Jul 28, 2024 • Veera M. Rajagopal

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Genes and transporters

Discovery of the human mitochondrial choline transporter

Jul 21, 2024 • Veera M. Rajagopal

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