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Genomes vs Exomes
Whole genome sequencing vs whole exome sequencing: which one is cost-effective for gene discovery?
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Veera M. Rajagopal

September 2024

Discovery of a major genetic risk factor for stroke in South Asians
Exome sequencing of 75k Pakistanis identifies a NOTCH3 genetic variant, accounting for 1-2% of strokes in South Asians
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Veera M. Rajagopal
De novo enhancer creation by a noncoding mutation
Genetic investigation of a cardiac arrhythmia reveals a new noncoding Mendelian disease mechanism
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Veera M. Rajagopal
6

August 2024

Discovery of TMEFF1, a viral restriction factor in the human brain
Exome sequencing of individuals with herpes simplex viral encephalitis identifies a new genetic mechanism through which neurons resist viral infections
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Veera M. Rajagopal
4
The Big tau: A new hope for Alzheimer's?
An overlooked tau isoform may hold the key to an effective Alzheimer's drug
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Veera M. Rajagopal
3

July 2024

How a jumping gene shaped the human skin color evolution
Two separate transposition events within ASIP, encoding agouti protein, have influenced the skin color changes during human evolution
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Veera M. Rajagopal
2
Genes and transporters
Discovery of the human mitochondrial choline transporter
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Veera M. Rajagopal
A noncoding RNA gene will solve genetic diagnoses for thousands
Whole genome sequencing discovers a small nuclear RNA gene RNU4-2 as one of the most frequent causes of neurodevelopmental disorders
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Veera M. Rajagopal
3
Nature's undoing of the curse of Colombian Alzheimer's families
Genetic modifiers of Alzheimer's disease-causing mutations
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Veera M. Rajagopal
2

June 2024

Human genetics and drug development
Growing evidence that human genetics can double or even triple drug development success rates
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Veera M. Rajagopal
Epstein-Barr Virus and IL27 signaling
Genetic deficiency for IL27 receptor predisposes to EBV infection but protects from EBV-associated cancer
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Veera M. Rajagopal
RAB32, a new Parkinson's gene
A new breakthrough in Parkinson's genetics
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Veera M. Rajagopal
© 2024 Veera M. Rajagopal
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