GWAS Stories
Subscribe
Sign in
Home
Deep dives
Round-up
Twitter Stories
xpost
Latest
Top
Discussions
A rare disease solves the mystery of a common drug
An ultrarare muscle disease caused by HMGCR mutations illuminate statins' controversial side effect
Apr 26
•
Veera M. Rajagopal
4
Share this post
A rare disease solves the mystery of a common drug
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
2
A receptor meets its ligand through human genetics
Happy Friday! Many things at work have been keeping me busy for the past many days. Still, I don’t miss taking a peek into my Twitter feeds now and then…
Apr 19
•
Veera M. Rajagopal
3
Share this post
A receptor meets its ligand through human genetics
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
The cost of waking a gene up from its eternal sleep
Noncoding de novo mutations release beta cell-specific repression of hexokinase to cause congenital hyperinsulinism
Apr 12
•
Veera M. Rajagopal
6
Share this post
The cost of waking a gene up from its eternal sleep
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
Discovery of a new obesity gene--Bassoon
Analyzing more than half a million exomes, scientists find that haploinsufficiency of a less known synaptic gene, BSN, causes extreme obesity
Apr 7
•
Veera M. Rajagopal
5
Share this post
Discovery of a new obesity gene--Bassoon
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
A non-coding mutation linked to extreme obesity
A tandem duplication rewires a tissue-specific gene to a ubiquitous promoter to cause extreme obesity
Apr 5
•
Veera M. Rajagopal
8
Share this post
A non-coding mutation linked to extreme obesity
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
The underappreciated role of rare disease in drug development
Happy Friday! I’ve been thinking about the role of rare diseases in drug development this week. Drug companies are racing to sequence healthy volunteers…
Mar 29
•
Veera M. Rajagopal
7
Share this post
The underappreciated role of rare disease in drug development
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
A common trick that drove some of the early human genetic discoveries
Happy Sunday! I am supposed to be working on something else. But I am here procrastinating on writing by writing. I was going through some key genetics…
Mar 24
•
Veera M. Rajagopal
5
Share this post
A common trick that drove some of the early human genetic discoveries
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
1
Decoding the FTO genetic puzzle
The story of scientists trying to crack open a low-hanging fruit they picked many years ago
Mar 22
•
Veera M. Rajagopal
6
Share this post
Decoding the FTO genetic puzzle
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
Insights from a deep dive into the genetics of Lp(a)
Genetic variants in LPA teach us about missing heritability, genetic differences between ancestries and allelic series
Mar 15
•
Veera M. Rajagopal
7
Share this post
Insights from a deep dive into the genetics of Lp(a)
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
1
De-risking drugs using genetics
Using Mendelian Randomization to de-risk EPO-increasing drugs
Mar 8
•
Veera M. Rajagopal
7
Share this post
De-risking drugs using genetics
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
Null mutations in interferon genes in Polynesia
Discovery of the founder mutations responsible for vaccination- and viral infection-associated deaths in Western Polynesians
Mar 1
•
Veera M. Rajagopal
5
Share this post
Null mutations in interferon genes in Polynesia
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
Looking back at a failed drug pipeline through the lens of human genetics
The rise and fall of DGAT1 inhibitors as obesity and type 2 diabetes drugs.
Feb 23
•
Veera M. Rajagopal
12
Share this post
Looking back at a failed drug pipeline through the lens of human genetics
www.gwasstories.com
Copy link
Facebook
Email
Note
Other
Share
Copy link
Facebook
Email
Note
Other
This site requires JavaScript to run correctly. Please
turn on JavaScript
or unblock scripts